Kidney Precision
Medicine for
Patients
The Humphreys Lab harnesses single-cell multiomics, kidney organoids, and computational biology to transform our understanding of kidney disease and develop new regenerative therapies.
How We Study the Kidney
Three complementary approaches — all aimed at understanding and treating human kidney disease with unprecedented resolution.
Single-Cell Multiomics
We apply snRNA-seq and snATAC-seq to mouse and human kidney and lung at scale, performing 100% of bioinformatic analyses in-house. Our datasets reveal cellular heterogeneity across disease states, drug responses, and developmental time points.
Kidney Organoids
We differentiate kidney organoids from human pluripotent stem cells to model development and disease in a dish. 3D light-sheet fluorescence microscopy and high-resolution confocal imaging reveal how nephron-like structures form and fail.
Regenerative Medicine
Translating molecular insights into therapies for AKI and CKD. We study cell-type-specific drug responses, identify new therapeutic targets, and develop strategies to regenerate injured kidney tissue.
High Resolution Microscopy
We use high-resolution confocal microscopy to visualize protein expression by immunofluorescence and mRNA by RNAscope.
Three-dimensional light sheet fluorescence microscopy reveals the branching architecture of nephron-like structures in kidney organoids differentiated from human pluripotent stem cells.
WashU Cellular Imaging →Kidney Integrative Transcriptomics
K.I.T. is our open-access single-cell data visualization platform — letting researchers worldwide explore our growing compendium of kidney single-cell RNA-seq data without needing bioinformatics expertise.
Browse cell populations, query gene expression across conditions and datasets, and download data for your own analyses. Trusted by researchers from 68 countries.
Launch K.I.T. →K.I.T.
Kidney Integrative Transcriptomics — explore millions of single-cell profiles from human & mouse kidney.
Recent Publications
A selection of key papers from the lab. View full bibliography on PubMed →
Our Team
A diverse group of scientists united by curiosity about kidney biology and driven to make an impact for patients.
Join the Lab
We are always seeking talented and motivated scientists who are passionate about kidney biology, single-cell genomics, and regenerative medicine. Positions are available at all career stages.
𝕏 @HumphreysLab in Benjamin Humphreys on LinkedIn 🔗 K.I.T. Single Cell Portal 📄 Full Bibliography on PubMedDivision of Nephrology · Department of Medicine
BJC Institute of Health · St. Louis, MO
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