single cell multiomics
We use single cell technologies to drive precision medicine
kidney organoids
We generate kidney organoids to model development & disease.
regenerative med
We develop treatments for human kidney diseases.
We use single cell technologies to drive precision medicine
We generate kidney organoids to model development & disease.
We develop treatments for human kidney diseases.
We use high resolution confocal microscopy to visualize expression of proteins by immunofluorescence, and mRNA by RNAscope. We also utilize three dimensional light sheet fluorescence microscopy to visualize branching of nephron-like structures in kidney organoids differentiated from human pluripotent stem cells.
A majority of the lab applies single nucleus RNA-seq and snATAC-seq to mouse and human kidney and lung. We have generated over 3M single cell RNA-seq and ATAC-seq libraries, and perform 100% of the bioinformatic analyses within the lab. See recent papers here, here and here. Our single cell data visualization tool Kidney Integrative Transcriptomics (K.I.T.) has had > 15,000 unique users from 68 different countries since its inception.
Watch the lab grow!